Transcription factors with Perturb-seq knockdown data for C2orf49-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf49-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf49-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:105,037,323–105,038,877 | 299.5 kb | Distal (>10kb) Multiome | 844 | |
| chr2:105,102,893–105,103,524 | 234.4 kb | Distal (>10kb) Multiome | 260 | |
| chr2:105,125,477–105,126,235 | 211.7 kb | Distal (>10kb) Multiome | 89 | |
| chr2:105,139,777–105,140,585 | 197.2 kb | Distal (>10kb) Multiome | 110 | |
| chr2:105,143,409–105,144,624 | 193.6 kb | Distal (>10kb) Multiome | 295 | |
| chr2:105,177,474–105,178,378 | 159.6 kb | Distal (>10kb) Multiome | 179 | |
| chr2:105,237,985–105,238,461 | 99.4 kb | Distal (>10kb) Multiome | 181 | |
| chr2:105,329,281–105,330,301 | 7.7 kb | Proximal (<10kb) Multiome | 799 | |
| chr2:105,337,038–105,338,021 | 32 bp | At TSS Multiome | 812 | |
| chr2:105,398,372–105,399,507 | 61.4 kb | Distal (>10kb) Multiome | 708 |
Genomic view of the C2orf49-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.