Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C2CD4C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2CD4C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2CD4C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:289,719–291,481 | 118.6 kb | Distal (>10kb) Multiome | 412 | |
| chr19:294,836–295,426 | 113.9 kb | Distal (>10kb) Multiome | 231 | |
| chr19:343,939–345,411 | 64.4 kb | Distal (>10kb) Multiome | 600 | |
| chr19:408,569–409,459 | 46 bp | At TSS Multiome | 310 | |
| chr19:459,789–461,382 | 51.0 kb | Distal (>10kb) Multiome | 545 | |
| chr19:461,557–462,453 | 52.9 kb | Distal (>10kb) Multiome | 580 | |
| chr19:488,399–489,918 | 80.0 kb | Distal (>10kb) Multiome | 898 | |
| chr19:506,451–508,366 | 98.0 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:510,509–511,797 | 101.7 kb | Distal (>10kb) Multiome | 739 | |
| chr19:518,865–519,356 | 109.9 kb | Distal (>10kb) Multiome | 151 | |
| chr19:530,809–533,397 | 122.3 kb | Distal (>10kb) Multiome | 856 | |
| chr19:572,071–573,594 | 163.3 kb | Distal (>10kb) Multiome | 888 | |
| chr19:588,127–589,976 | 179.2 kb | Distal (>10kb) Multiome | 526 | |
| chr19:632,653–633,806 | 224.5 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 230.6 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 254.2 kb | Distal (>10kb) Multiome | 723 | |
| chr19:679,616–681,731 | 271.6 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 294.9 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 299.7 kb | Distal (>10kb) Multiome | 317 |
Genomic view of the C2CD4C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.