Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1orf198. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1orf198 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1orf198, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:230,576,014–230,576,719 | 292.2 kb | Distal (>10kb) Multiome | 84 | |
| chr1:230,641,860–230,643,036 | 226.1 kb | Distal (>10kb) Multiome | 985 | |
| chr1:230,753,346–230,754,251 | 114.6 kb | Distal (>10kb) Multiome | 356 | |
| chr1:230,867,716–230,869,411 | 117 bp | At TSS Multiome | 758 | |
| chr1:230,882,687–230,883,179 | 14.5 kb | Distal (>10kb) Multiome | 18 | |
| chr1:230,978,084–230,979,476 | 110.4 kb | Distal (>10kb) Multiome | 931 | |
| chr1:231,037,684–231,038,550 | 169.6 kb | Distal (>10kb) Multiome | 274 | |
| chr1:231,039,156–231,041,267 | 171.8 kb | Distal (>10kb) Multiome | 661 | |
| chr1:231,065,566–231,066,080 | 197.3 kb | Distal (>10kb) Multiome | 199 | |
| chr1:231,161,989–231,163,833 | 293.9 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the C1orf198 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.