Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1orf159. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1orf159 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1orf159, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:904,256–904,920 | 211.3 kb | Distal (>10kb) Multiome | 590 | |
| chr1:923,612–925,339 | 192.2 kb | Distal (>10kb) Multiome | 500 | |
| chr1:939,835–943,080 | 174.2 kb | Distal (>10kb) Multiome | 864 | |
| chr1:959,035–960,017 | 156.8 kb | Distal (>10kb) Multiome | 622 | |
| chr1:960,291–961,429 | 155.3 kb | Distal (>10kb) Multiome | 552 | |
| chr1:975,960–976,521 | 139.8 kb | Distal (>10kb) Multiome | 476 | |
| chr1:998,350–1,000,999 | 115.7 kb | Distal (>10kb) Multiome | 1047 | |
| chr1:1,001,349–1,002,099 | 114.1 kb | Distal (>10kb) Multiome | 646 | |
| chr1:1,005,015–1,005,702 | 110.8 kb | Distal (>10kb) Multiome | 532 | |
| chr1:1,019,142–1,021,414 | 96.5 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 82.9 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 75.1 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 56.5 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 46.9 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 36.0 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 173 bp | At TSS Multiome | 743 | |
| chr1:1,122,160–1,122,423 | 6.1 kb | Proximal (<10kb) | 445 | |
| chr1:1,157,424–1,158,362 | 41.5 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 85.3 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 116.1 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 157.9 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 177.8 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,307,375–1,310,219 | 192.2 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 208.7 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 233.5 kb | Distal (>10kb) Multiome | 539 | |
| chr1:1,353,403–1,354,425 | 237.8 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,374,767–1,375,798 | 259.3 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 283.4 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 291.3 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the C1orf159 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.