Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C15orf39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C15orf39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C15orf39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,905,926–74,907,376 | 295.1 kb | Distal (>10kb) Multiome | 743 | |
| chr15:74,937,494–74,938,710 | 263.8 kb | Distal (>10kb) Multiome | 998 | |
| chr15:74,950,147–74,950,911 | 251.3 kb | Distal (>10kb) Multiome | 326 | |
| chr15:74,955,873–74,957,720 | 245.0 kb | Distal (>10kb) Multiome | 776 | |
| chr15:74,958,363–74,959,586 | 243.3 kb | Distal (>10kb) Multiome | 282 | |
| chr15:74,995,116–74,996,280 | 206.3 kb | Distal (>10kb) Multiome | 825 | |
| chr15:75,023,365–75,023,895 | 178.3 kb | Distal (>10kb) Multiome HiCAR | 822 | |
| chr15:75,178,233–75,178,833 | 23.4 kb | Distal (>10kb) Multiome | 386 | |
| chr15:75,195,479–75,195,740 | 6.1 kb | Proximal (<10kb) | 122 | |
| chr15:75,195,843–75,196,256 | 5.6 kb | Proximal (<10kb) | 103 | |
| chr15:75,200,527–75,203,502 | 1.2 kb | Proximal (<10kb) Multiome | 928 | |
| chr15:75,204,742–75,205,092 | 2.9 kb | Proximal (<10kb) | 642 | |
| chr15:75,335,855–75,336,339 | 134.2 kb | Distal (>10kb) Multiome | 665 | |
| chr15:75,346,877–75,348,733 | 145.6 kb | Distal (>10kb) Multiome | 738 | |
| chr15:75,367,625–75,369,002 | 166.3 kb | Distal (>10kb) Multiome | 1121 | |
| chr15:75,450,273–75,456,388 | 250.1 kb | Distal (>10kb) Multiome | 1174 |
Genomic view of the C15orf39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.