Enables hydrolase activity, acting on ester bonds and zinc ion binding activity. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for C11orf54. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C11orf54 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C11orf54, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:93,444,389–93,445,160 | 296.8 kb | Distal (>10kb) Multiome | 173 | |
| chr11:93,542,187–93,543,870 | 198.2 kb | Distal (>10kb) Multiome | 790 | |
| chr11:93,624,139–93,625,031 | 117.0 kb | Distal (>10kb) Multiome | 122 | |
| chr11:93,661,372–93,662,246 | 79.9 kb | Distal (>10kb) Multiome | 1008 | |
| chr11:93,740,057–93,740,457 | 1.1 kb | Proximal (<10kb) | 169 | |
| chr11:93,740,823–93,742,225 | 34 bp | At TSS Multiome | 900 | |
| chr11:93,745,039–93,745,387 | 3.4 kb | Proximal (<10kb) | 155 | |
| chr11:93,765,352–93,766,055 | 24.2 kb | Distal (>10kb) Multiome | 124 | |
| chr11:93,770,077–93,770,855 | 28.9 kb | Distal (>10kb) Multiome | 100 | |
| chr11:93,783,874–93,784,997 | 42.7 kb | Distal (>10kb) Multiome | 860 | |
| chr11:93,849,777–93,850,638 | 108.7 kb | Distal (>10kb) Multiome | 277 | |
| chr11:93,871,397–93,872,351 | 130.4 kb | Distal (>10kb) Multiome | 72 | |
| chr11:93,903,808–93,904,283 | 162.5 kb | Distal (>10kb) Multiome | 40 | |
| chr11:93,907,116–93,907,874 | 166.1 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the C11orf54 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.