BTN2A1
butyrophilin subfamily 2 member A1 | BT2.1, BTF1, BTN2.1

This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Member of: DE-10
Biological processes 8 terms
Expression (TPM)
BTN2A1 — as a Regulated Gene

TFs regulating BTN2A1 0 TFs

Transcription factors with Perturb-seq knockdown data for BTN2A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTN2A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BTN2A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTN2A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:26,156,184–26,158,744 299.9 kb Distal (>10kb) Multiome 1310
chr6:26,171,798–26,172,499 286.0 kb Distal (>10kb) Multiome 580
chr6:26,183,128–26,184,377 274.2 kb Distal (>10kb) Multiome 311
chr6:26,187,874–26,189,538 268.9 kb Distal (>10kb) Multiome 1053
chr6:26,196,695–26,197,676 260.7 kb Distal (>10kb) Multiome 842
chr6:26,198,203–26,200,197 258.5 kb Distal (>10kb) Multiome 939
chr6:26,203,791–26,205,119 253.5 kb Distal (>10kb) Multiome 1071
chr6:26,214,872–26,218,468 241.1 kb Distal (>10kb) Multiome 1096
chr6:26,223,716–26,224,480 233.9 kb Distal (>10kb) Multiome 507
chr6:26,224,856–26,226,566 232.7 kb Distal (>10kb) Multiome 451
chr6:26,239,944–26,240,920 217.6 kb Distal (>10kb) Multiome 375
chr6:26,249,682–26,251,138 207.6 kb Distal (>10kb) Multiome 731
chr6:26,251,339–26,252,079 206.2 kb Distal (>10kb) Multiome 445
chr6:26,270,815–26,273,967 185.0 kb Distal (>10kb) Multiome 742
chr6:26,285,011–26,286,121 172.4 kb Distal (>10kb) Multiome 1121
chr6:26,304,972–26,305,585 152.6 kb Distal (>10kb) Multiome 586
chr6:26,312,505–26,313,475 144.9 kb Distal (>10kb) Multiome 896
chr6:26,322,092–26,323,232 135.3 kb Distal (>10kb) Multiome 811
chr6:26,327,476–26,328,318 129.8 kb Distal (>10kb) Multiome 716
chr6:26,341,545–26,342,139 116.2 kb Distal (>10kb) Multiome HiCAR 716
chr6:26,365,073–26,365,647 92.6 kb Distal (>10kb) Multiome 587
chr6:26,382,957–26,383,951 74.8 kb Distal (>10kb) Multiome 448
chr6:26,421,258–26,421,866 36.5 kb Distal (>10kb) Multiome 473
chr6:26,457,390–26,458,395 63 bp At TSS Multiome 525
chr6:26,473,842–26,474,357 16.2 kb Distal (>10kb) Multiome 487
chr6:26,520,324–26,522,398 63.0 kb Distal (>10kb) Multiome 1082
chr6:26,532,765–26,533,409 75.1 kb Distal (>10kb) Multiome 830
chr6:26,537,180–26,538,912 80.4 kb Distal (>10kb) Multiome 1114
chr6:26,550,296–26,550,971 92.7 kb Distal (>10kb) Multiome 695
chr6:26,553,165–26,553,642 95.6 kb Distal (>10kb) Multiome 561
chr6:26,553,738–26,555,437 96.2 kb Distal (>10kb) Multiome 779
chr6:26,556,432–26,557,038 98.6 kb Distal (>10kb) Multiome 676
chr6:26,571,613–26,572,233 114.0 kb Distal (>10kb) Multiome 861
chr6:26,595,619–26,596,282 137.9 kb Distal (>10kb) Multiome 798
chr6:26,596,497–26,597,408 139.0 kb Distal (>10kb) Multiome 940
chr6:26,659,338–26,660,351 201.8 kb Distal (>10kb) Multiome 748

Genome Browser

Genomic view of the BTN2A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:26,146,184 – 26,670,351
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq