This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for BTAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:91,632,611–91,633,844 | 290.6 kb | Distal (>10kb) Multiome | 874 | |
| chr10:91,745,021–91,745,730 | 178.4 kb | Distal (>10kb) Multiome | 223 | |
| chr10:91,798,050–91,799,545 | 125.3 kb | Distal (>10kb) Multiome | 902 | |
| chr10:91,879,304–91,880,277 | 44.0 kb | Distal (>10kb) Multiome | 134 | |
| chr10:91,883,605–91,884,441 | 39.7 kb | Distal (>10kb) Multiome | 290 | |
| chr10:91,887,103–91,887,953 | 36.4 kb | Distal (>10kb) Multiome | 657 | |
| chr10:91,908,112–91,909,644 | 15.0 kb | Distal (>10kb) Multiome | 944 | |
| chr10:91,923,397–91,924,310 | 32 bp | At TSS Multiome | 981 | |
| chr10:92,045,582–92,046,227 | 122.1 kb | Distal (>10kb) Multiome | 132 | |
| chr10:92,087,615–92,088,099 | 164.2 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the BTAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.