Enables RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BRIX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRIX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRIX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:34,474,588–34,475,820 | 440.3 kb | Distal (>10kb) Multiome HiCAR | 304 | |
| chr5:34,655,322–34,657,880 | 259.4 kb | Distal (>10kb) Multiome | 808 | |
| chr5:34,838,509–34,839,735 | 76.5 kb | Distal (>10kb) Multiome | 893 | |
| chr5:34,914,780–34,916,174 | 173 bp | At TSS Multiome | 956 | |
| chr5:34,929,003–34,930,376 | 13.8 kb | Distal (>10kb) Multiome | 783 |
Genomic view of the BRIX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.