BRD8
bromodomain containing 8 | SMAP, p120

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

Member of: DE-11
Biological processes 19 terms
NuA4 histone acetyltransferase complex (GO:0035267)NuA4 histone acetyltransferase complex (GO:0035267)Swr1 complex (GO:0000812)cell surface receptor signaling pathway (GO:0007166)cellular response to thyroid hormone stimulus (GO:0097067)nuclear thyroid hormone receptor binding (GO:0046966)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of double-strand break repair via homologous recombination (GO:1905168)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of apoptotic process (GO:0042981)regulation of cell cycle (GO:0051726)regulation of double-strand break repair (GO:2000779)transcription coactivator activity (GO:0003713)
Expression (TPM)
BRD8 — as a Regulated Gene

TFs regulating BRD8 0 TFs

Transcription factors with Perturb-seq knockdown data for BRD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BRD8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr5:138,032,174–138,033,856 145.9 kb Distal (>10kb) Multiome 889
chr5:138,036,018–138,036,514 142.8 kb Distal (>10kb) Multiome 359
chr5:138,095,141–138,095,876 83.5 kb Distal (>10kb) Multiome 194
chr5:138,178,003–138,178,116 516 bp At TSS 125
chr5:138,178,349–138,179,428 67 bp At TSS Multiome 789
chr5:138,212,899–138,214,126 34.5 kb Distal (>10kb) Multiome 747
chr5:138,241,684–138,242,313 63.1 kb Distal (>10kb) Multiome 397
chr5:138,247,699–138,248,212 69.0 kb Distal (>10kb) Multiome 13
chr5:138,274,126–138,274,706 95.4 kb Distal (>10kb) Multiome 161
chr5:138,331,426–138,332,354 153.0 kb Distal (>10kb) Multiome 686
chr5:138,337,358–138,339,397 159.2 kb Distal (>10kb) Multiome 1134
chr5:138,352,125–138,353,730 173.7 kb Distal (>10kb) Multiome 868
chr5:138,438,317–138,439,353 260.0 kb Distal (>10kb) Multiome 421
chr5:138,449,690–138,450,452 271.2 kb Distal (>10kb) Multiome 486
chr5:138,463,424–138,467,199 286.2 kb Distal (>10kb) Multiome 1117

Genome Browser

Genomic view of the BRD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr5:138,022,174 – 138,477,199
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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