The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BRAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:111,404,305–111,407,139 | 280.3 kb | Distal (>10kb) Multiome | 928 | |
| chr12:111,597,725–111,600,125 | 86.4 kb | Distal (>10kb) Multiome | 973 | |
| chr12:111,685,452–111,686,504 | 61 bp | At TSS Multiome | 858 | |
| chr12:111,766,539–111,767,436 | 81.0 kb | Distal (>10kb) Multiome | 732 | |
| chr12:111,775,668–111,776,178 | 90.0 kb | Distal (>10kb) Multiome | 448 | |
| chr12:111,841,636–111,842,766 | 156.1 kb | Distal (>10kb) Multiome | 963 | |
| chr12:111,967,710–111,968,344 | 282.1 kb | Distal (>10kb) Multiome | 26 |
Genomic view of the BRAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.