BOP1
BOP1 ribosomal biogenesis factor | KIAA0124

Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 Developmental clusters: GC1
Biological processes 33 terms
PeBoW complex (GO:0070545)PeBoW complex (GO:0070545)RNA binding (GO:0003723)cell population proliferation (GO:0008283)chromosome (GO:0005694)cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000448)maturation of 5.8S rRNA (GO:0000460)maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000466)maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463)maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463)maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)preribosome, large subunit precursor (GO:0030687)preribosome, large subunit precursor (GO:0030687)protein binding (GO:0005515)rRNA processing (GO:0006364)rRNA processing (GO:0006364)regulation of cell cycle (GO:0051726)regulation of signal transduction by p53 class mediator (GO:1901796)ribonucleoprotein complex (GO:1990904)ribonucleoprotein complex binding (GO:0043021)ribonucleoprotein complex binding (GO:0043021)ribosomal large subunit assembly (GO:0000027)ribosomal large subunit biogenesis (GO:0042273)ribosomal large subunit biogenesis (GO:0042273)ribosome biogenesis (GO:0042254)ribosome biogenesis (GO:0042254)ribosome biogenesis (GO:0042254)
Expression (TPM)
BOP1 — as a Regulated Gene

TFs regulating BOP1 0 TFs

Transcription factors with Perturb-seq knockdown data for BOP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BOP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BOP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BOP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:144,049,063–144,051,761 240.8 kb Distal (>10kb) Multiome 342
chr8:144,060,259–144,061,087 230.7 kb Distal (>10kb) Multiome 727
chr8:144,078,142–144,079,235 212.8 kb Distal (>10kb) Multiome 912
chr8:144,082,187–144,083,105 208.9 kb Distal (>10kb) Multiome 763
chr8:144,094,454–144,095,491 196.5 kb Distal (>10kb) Multiome 798
chr8:144,103,485–144,105,242 187.1 kb Distal (>10kb) Multiome 1033
chr8:144,108,038–144,108,663 183.1 kb Distal (>10kb) Multiome 137
chr8:144,137,565–144,138,500 153.7 kb Distal (>10kb) Multiome HiCAR 817
chr8:144,146,820–144,149,073 143.5 kb Distal (>10kb) Multiome 790
chr8:144,266,293–144,267,098 24.9 kb Distal (>10kb) Multiome 162
chr8:144,290,981–144,292,410 72 bp At TSS Multiome 716
chr8:144,315,833–144,316,450 24.7 kb Distal (>10kb) Multiome HiCAR 396
chr8:144,325,768–144,327,719 35.5 kb Distal (>10kb) Multiome HiCAR 1016
chr8:144,331,281–144,333,847 40.6 kb Distal (>10kb) Multiome 406
chr8:144,336,102–144,339,119 45.5 kb Distal (>10kb) Multiome 922
chr8:144,353,907–144,355,227 63.1 kb Distal (>10kb) Multiome 280
chr8:144,358,142–144,359,070 67.1 kb Distal (>10kb) Multiome 719
chr8:144,369,349–144,369,916 78.3 kb Distal (>10kb) Multiome 204
chr8:144,372,497–144,372,883 81.3 kb Distal (>10kb) Multiome 160
chr8:144,372,993–144,375,084 82.5 kb Distal (>10kb) Multiome 903
chr8:144,408,968–144,410,189 118.0 kb Distal (>10kb) Multiome 920
chr8:144,427,691–144,429,571 137.1 kb Distal (>10kb) Multiome 1000
chr8:144,443,691–144,445,047 152.9 kb Distal (>10kb) Multiome 743
chr8:144,462,568–144,463,422 171.5 kb Distal (>10kb) Multiome 548
chr8:144,463,885–144,468,178 174.3 kb Distal (>10kb) Multiome 910
chr8:144,471,960–144,474,391 181.1 kb Distal (>10kb) Multiome 482
chr8:144,474,517–144,476,543 184.4 kb Distal (>10kb) Multiome 321
chr8:144,477,277–144,478,749 186.6 kb Distal (>10kb) Multiome 679
chr8:144,478,851–144,479,509 187.9 kb Distal (>10kb) Multiome 392
chr8:144,483,979–144,484,843 192.9 kb Distal (>10kb) Multiome 125
chr8:144,495,748–144,496,431 204.7 kb Distal (>10kb) Multiome 131
chr8:144,500,182–144,501,505 209.6 kb Distal (>10kb) Multiome 484
chr8:144,507,995–144,510,268 217.4 kb Distal (>10kb) Multiome 1067
chr8:144,517,168–144,518,442 226.5 kb Distal (>10kb) Multiome 637
chr8:144,521,935–144,523,450 231.1 kb Distal (>10kb) Multiome 663
chr8:144,524,105–144,525,099 233.2 kb Distal (>10kb) Multiome 264
chr8:144,526,399–144,529,305 235.6 kb Distal (>10kb) Multiome 934
chr8:144,529,455–144,530,630 238.7 kb Distal (>10kb) Multiome 284
chr8:144,580,290–144,581,657 289.3 kb Distal (>10kb) Multiome 271

Genome Browser

Genomic view of the BOP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:144,039,063 – 144,591,657
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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