The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for BOK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BOK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BOK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:241,272,147–241,273,188 | 285.9 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 243.2 kb | Distal (>10kb) Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 203.7 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 202.6 kb | Distal (>10kb) Multiome | 680 | |
| chr2:241,507,257–241,509,444 | 50.0 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:241,540,846–241,542,485 | 17.4 kb | Distal (>10kb) Multiome | 394 | |
| chr2:241,555,780–241,556,049 | 2.7 kb | Proximal (<10kb) | 87 | |
| chr2:241,558,542–241,559,899 | 30 bp | At TSS Multiome | 638 | |
| chr2:241,609,833–241,610,860 | 51.6 kb | Distal (>10kb) Multiome | 755 | |
| chr2:241,636,378–241,638,145 | 78.7 kb | Distal (>10kb) Multiome | 934 | |
| chr2:241,686,350–241,687,468 | 128.2 kb | Distal (>10kb) Multiome | 895 | |
| chr2:241,701,038–241,703,402 | 142.7 kb | Distal (>10kb) Multiome | 1081 | |
| chr2:241,734,032–241,735,695 | 175.8 kb | Distal (>10kb) Multiome | 977 | |
| chr2:241,843,948–241,844,465 | 285.5 kb | Distal (>10kb) Multiome | 429 |
Genomic view of the BOK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.