The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for BLVRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BLVRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BLVRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:43,582,521–43,583,972 | 175.7 kb | Distal (>10kb) Multiome | 861 | |
| chr7:43,729,165–43,729,933 | 29.1 kb | Distal (>10kb) Multiome | 896 | |
| chr7:43,750,218–43,750,426 | 8.3 kb | Proximal (<10kb) | 155 | |
| chr7:43,750,522–43,750,878 | 7.8 kb | Proximal (<10kb) | 155 | |
| chr7:43,758,058–43,759,333 | 78 bp | At TSS Multiome | 665 | |
| chr7:43,768,339–43,769,124 | 9.7 kb | Proximal (<10kb) | 179 | |
| chr7:43,838,582–43,839,204 | 80.3 kb | Distal (>10kb) Multiome | 647 | |
| chr7:43,868,905–43,870,110 | 110.8 kb | Distal (>10kb) Multiome | 804 | |
| chr7:43,905,962–43,907,078 | 147.9 kb | Distal (>10kb) Multiome | 557 | |
| chr7:43,926,113–43,927,072 | 167.9 kb | Distal (>10kb) Multiome | 1004 | |
| chr7:43,985,975–43,986,501 | 227.6 kb | Distal (>10kb) Multiome | 113 | |
| chr7:44,018,938–44,019,667 | 260.6 kb | Distal (>10kb) Multiome | 564 | |
| chr7:44,038,952–44,039,494 | 280.5 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,044,335–44,045,323 | 286.0 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the BLVRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.