This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for BEX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BEX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BEX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,101,365–103,102,296 | 113.3 kb | Distal (>10kb) Multiome | 252 | |
| chrX:103,211,129–103,211,306 | 3.8 kb | Proximal (<10kb) | 62 | |
| chrX:103,214,792–103,216,027 | 9 bp | At TSS Multiome | 433 | |
| chrX:103,254,119–103,255,539 | 40.3 kb | Distal (>10kb) Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 95.9 kb | Distal (>10kb) Multiome | 289 | |
| chrX:103,376,152–103,376,747 | 161.3 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,431,896–103,432,874 | 217.3 kb | Distal (>10kb) Multiome | 6 |
Genomic view of the BEX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.