The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for BCORL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCORL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCORL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:129,843,268–129,844,298 | 138.7 kb | Distal (>10kb) Multiome | 523 | |
| chrX:129,905,717–129,906,258 | 76.6 kb | Distal (>10kb) Multiome | 664 | |
| chrX:129,931,017–129,933,134 | 50.2 kb | Distal (>10kb) Multiome | 620 | |
| chrX:129,957,138–129,957,761 | 25.2 kb | Distal (>10kb) Multiome | 491 | |
| chrX:129,961,005–129,961,747 | 21.2 kb | Distal (>10kb) Multiome | 424 | |
| chrX:129,980,591–129,981,090 | 1.5 kb | Proximal (<10kb) | 235 | |
| chrX:129,982,008–129,982,922 | 111 bp | At TSS Multiome | 614 | |
| chrX:129,984,009–129,984,684 | 1.7 kb | Proximal (<10kb) Multiome | 240 | |
| chrX:130,060,034–130,061,017 | 77.9 kb | Distal (>10kb) Multiome | 583 | |
| chrX:130,120,389–130,121,207 | 138.3 kb | Distal (>10kb) Multiome | 517 | |
| chrX:130,165,452–130,166,368 | 183.3 kb | Distal (>10kb) Multiome | 754 | |
| chrX:130,268,321–130,269,066 | 286.2 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the BCORL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.