BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BCL9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:147,242,264–147,243,635 | 298.7 kb | Distal (>10kb) Multiome | 943 | |
| chr1:147,504,803–147,505,299 | 36.4 kb | Distal (>10kb) Multiome HiCAR | 199 | |
| chr1:147,538,758–147,538,937 | 2.6 kb | Proximal (<10kb) | 33 | |
| chr1:147,540,314–147,540,507 | 992 bp | At TSS | 100 | |
| chr1:147,540,743–147,542,280 | 111 bp | At TSS Multiome | 562 | |
| chr1:147,545,137–147,545,527 | 3.6 kb | Proximal (<10kb) | 230 | |
| chr1:147,598,654–147,600,842 | 58.4 kb | Distal (>10kb) Multiome | 743 | |
| chr1:147,669,496–147,671,101 | 129.1 kb | Distal (>10kb) Multiome | 793 | |
| chr1:147,820,658–147,821,597 | 279.6 kb | Distal (>10kb) Multiome | 92 | |
| chr1:147,833,206–147,834,500 | 292.6 kb | Distal (>10kb) Multiome | 152 |
Genomic view of the BCL9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.