Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; positive regulation of catalytic activity; and positive regulation of transcription by RNA polymerase II. Located in euchromatin; nucleus; and phagophore assembly site. Implicated in Hengel-Maroofian-Schols syndrome. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BCAS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCAS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCAS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:60,384,860–60,385,543 | 292.7 kb | Distal (>10kb) Multiome | 76 | |
| chr17:60,391,203–60,392,936 | 285.6 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:60,421,283–60,422,169 | 256.2 kb | Distal (>10kb) Multiome | 479 | |
| chr17:60,525,577–60,526,500 | 151.7 kb | Distal (>10kb) Multiome | 955 | |
| chr17:60,579,473–60,580,626 | 97.9 kb | Distal (>10kb) Multiome | 205 | |
| chr17:60,599,336–60,601,434 | 77.7 kb | Distal (>10kb) Multiome | 1120 | |
| chr17:60,676,921–60,678,448 | 144 bp | At TSS Multiome | 986 | |
| chr17:61,395,593–61,397,794 | 719.5 kb | Distal (>10kb) Multiome HiCAR | 334 | |
| chr17:61,398,963–61,400,696 | 721.7 kb | Distal (>10kb) Multiome HiCAR | 714 | |
| chr17:61,464,680–61,465,281 | 787.0 kb | Distal (>10kb) Multiome HiCAR | 80 |
Genomic view of the BCAS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.