The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for BANF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BANF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BANF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,711,437–65,712,942 | 290.3 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 281.9 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 222.5 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 214.2 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 184.3 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 168.8 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 145.5 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 142.0 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 128.9 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 114.0 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 111.9 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 102.0 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 83.3 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 40.9 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 175 bp | At TSS Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 4.9 kb | Proximal (<10kb) Multiome | 100 | |
| chr11:66,010,080–66,010,400 | 7.8 kb | Proximal (<10kb) | 13 | |
| chr11:66,022,341–66,022,903 | 20.0 kb | Distal (>10kb) Multiome | 466 | |
| chr11:66,045,170–66,045,637 | 42.8 kb | Distal (>10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 46.6 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 49.6 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,069,690–66,071,102 | 67.6 kb | Distal (>10kb) Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 255.3 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 264.9 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 275.5 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 280.0 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 286.8 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the BANF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.