This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for BAIAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAIAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAIAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,048,353–1,048,991 | 294.7 kb | Distal (>10kb) Multiome | 220 | |
| chr16:1,088,257–1,088,904 | 254.7 kb | Distal (>10kb) Multiome | 201 | |
| chr16:1,102,896–1,103,532 | 240.2 kb | Distal (>10kb) Multiome | 331 | |
| chr16:1,152,124–1,154,512 | 190.4 kb | Distal (>10kb) Multiome | 341 | |
| chr16:1,300,823–1,301,358 | 42.2 kb | Distal (>10kb) Multiome | 419 | |
| chr16:1,308,686–1,309,923 | 34.1 kb | Distal (>10kb) Multiome | 953 | |
| chr16:1,331,603–1,332,817 | 11.3 kb | Distal (>10kb) Multiome | 492 | |
| chr16:1,333,312–1,334,056 | 9.7 kb | Proximal (<10kb) Multiome | 271 | |
| chr16:1,342,604–1,343,805 | 129 bp | At TSS Multiome | 560 | |
| chr16:1,351,418–1,352,242 | 8.6 kb | Proximal (<10kb) Multiome | 733 | |
| chr16:1,378,844–1,380,439 | 36.5 kb | Distal (>10kb) Multiome | 782 | |
| chr16:1,408,010–1,408,819 | 65.0 kb | Distal (>10kb) Multiome | 546 | |
| chr16:1,413,643–1,415,278 | 71.5 kb | Distal (>10kb) Multiome | 661 | |
| chr16:1,420,269–1,421,402 | 77.6 kb | Distal (>10kb) Multiome | 897 | |
| chr16:1,474,566–1,475,411 | 131.8 kb | Distal (>10kb) Multiome | 915 | |
| chr16:1,492,797–1,493,962 | 150.0 kb | Distal (>10kb) Multiome | 710 | |
| chr16:1,610,035–1,611,264 | 267.3 kb | Distal (>10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 268.9 kb | Distal (>10kb) Multiome | 718 |
Genomic view of the BAIAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.