B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]
Transcription factors with Perturb-seq knockdown data for B4GALNT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B4GALNT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B4GALNT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:188,514–189,385 | 270.8 kb | Distal (>10kb) Multiome | 399 | |
| chr12:203,433–204,150 | 256.1 kb | Distal (>10kb) Multiome | 173 | |
| chr12:219,759–220,243 | 239.9 kb | Distal (>10kb) Multiome | 454 | |
| chr12:253,958–254,560 | 205.6 kb | Distal (>10kb) Multiome | 30 | |
| chr12:459,530–460,568 | 18 bp | At TSS Multiome | 338 | |
| chr12:509,461–510,940 | 50.5 kb | Distal (>10kb) Multiome | 399 | |
| chr12:569,602–571,188 | 110.0 kb | Distal (>10kb) Multiome | 800 | |
| chr12:642,622–643,509 | 183.1 kb | Distal (>10kb) Multiome | 556 | |
| chr12:669,635–670,134 | 209.9 kb | Distal (>10kb) Multiome | 33 | |
| chr12:740,453–741,486 | 281.1 kb | Distal (>10kb) Multiome | 114 | |
| chr12:751,121–751,920 | 291.3 kb | Distal (>10kb) Multiome | 860 | |
| chr12:752,026–753,528 | 292.6 kb | Distal (>10kb) Multiome | 747 |
Genomic view of the B4GALNT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.