This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for B3GNT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B3GNT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B3GNT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:61,905,370–61,906,012 | 290.4 kb | Distal (>10kb) Multiome | 819 | |
| chr2:61,924,970–61,925,711 | 270.7 kb | Distal (>10kb) Multiome | 28 | |
| chr2:62,108,942–62,110,921 | 86.2 kb | Distal (>10kb) Multiome | 186 | |
| chr2:62,194,988–62,196,964 | 58 bp | At TSS Multiome | 910 | |
| chr2:62,197,711–62,198,027 | 1.6 kb | Proximal (<10kb) | 242 | |
| chr2:62,293,519–62,294,404 | 97.9 kb | Distal (>10kb) Multiome | 525 | |
| chr2:62,330,564–62,331,250 | 134.8 kb | Distal (>10kb) Multiome | 71 | |
| chr2:62,354,891–62,355,450 | 159.1 kb | Distal (>10kb) Multiome | 146 | |
| chr2:62,370,563–62,371,206 | 174.9 kb | Distal (>10kb) Multiome | 41 | |
| chr2:62,411,213–62,412,364 | 215.7 kb | Distal (>10kb) Multiome | 534 | |
| chr2:62,456,637–62,457,880 | 261.0 kb | Distal (>10kb) Multiome | 814 |
Genomic view of the B3GNT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.