This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for B2M. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B2M upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B2M, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:44,426,579–44,428,620 | 284.3 kb | Distal (>10kb) Multiome | 941 | |
| chr15:44,536,026–44,537,829 | 174.5 kb | Distal (>10kb) Multiome | 958 | |
| chr15:44,663,054–44,664,141 | 47.8 kb | Distal (>10kb) Multiome | 1030 | |
| chr15:44,683,274–44,683,762 | 28.1 kb | Distal (>10kb) Multiome | 211 | |
| chr15:44,710,930–44,712,219 | 10 bp | At TSS Multiome | 782 | |
| chr15:44,728,448–44,729,627 | 17.5 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the B2M locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.