Predicted to enable RNA binding activity and chromatin binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of transcription by RNA polymerase II; and social behavior. Predicted to act upstream of or within extracellular matrix organization; lung alveolus development; and positive regulation of hematopoietic stem cell proliferation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATXN1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATXN1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATXN1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,564,628–71,565,649 | 280.9 kb | Distal (>10kb) Multiome | 792 | |
| chr16:71,625,835–71,627,289 | 219.8 kb | Distal (>10kb) Multiome | 594 | |
| chr16:71,722,829–71,724,442 | 122.8 kb | Distal (>10kb) Multiome | 894 | |
| chr16:71,808,251–71,809,603 | 36.8 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:71,845,428–71,846,392 | 27 bp | At TSS Multiome | 923 | |
| chr16:71,883,009–71,884,742 | 38.2 kb | Distal (>10kb) Multiome | 791 | |
| chr16:71,894,288–71,896,022 | 49.4 kb | Distal (>10kb) Multiome | 1139 | |
| chr16:71,981,752–71,982,390 | 136.1 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,008,426–72,009,172 | 162.7 kb | Distal (>10kb) Multiome | 815 | |
| chr16:72,013,585–72,014,228 | 168.1 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,093,288–72,094,355 | 247.8 kb | Distal (>10kb) Multiome | 860 | |
| chr16:72,111,833–72,112,319 | 266.2 kb | Distal (>10kb) Multiome | 60 |
Genomic view of the ATXN1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.