This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for ATRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:3,172,885–3,174,573 | 297.4 kb | Distal (>10kb) Multiome | 1012 | |
| chr20:3,203,485–3,204,801 | 266.5 kb | Distal (>10kb) Multiome | 952 | |
| chr20:3,218,394–3,218,992 | 252.3 kb | Distal (>10kb) Multiome | 638 | |
| chr20:3,238,062–3,240,422 | 231.6 kb | Distal (>10kb) Multiome | 714 | |
| chr20:3,407,081–3,408,415 | 63.2 kb | Distal (>10kb) Multiome | 825 | |
| chr20:3,408,525–3,409,169 | 62.0 kb | Distal (>10kb) Multiome | 453 | |
| chr20:3,470,330–3,471,668 | 9 bp | At TSS Multiome | 975 | |
| chr20:3,672,530–3,673,055 | 201.7 kb | Distal (>10kb) Multiome | 158 | |
| chr20:3,681,778–3,682,557 | 211.2 kb | Distal (>10kb) Multiome | 170 | |
| chr20:3,732,150–3,733,030 | 261.6 kb | Distal (>10kb) Multiome | 192 | |
| chr20:3,744,813–3,745,795 | 274.2 kb | Distal (>10kb) Multiome | 379 | |
| chr20:3,749,619–3,750,251 | 278.9 kb | Distal (>10kb) Multiome | 520 | |
| chr20:3,751,352–3,752,738 | 281.1 kb | Distal (>10kb) Multiome | 261 | |
| chr20:3,767,155–3,768,879 | 296.9 kb | Distal (>10kb) Multiome | 1011 |
Genomic view of the ATRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.