The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for ATR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:142,447,330–142,448,346 | 130.7 kb | Distal (>10kb) Multiome | 859 | |
| chr3:142,568,423–142,569,093 | 10.1 kb | Distal (>10kb) Multiome | 163 | |
| chr3:142,577,802–142,577,948 | 784 bp | At TSS | 76 | |
| chr3:142,578,047–142,578,156 | 576 bp | At TSS | 92 | |
| chr3:142,578,301–142,579,268 | 94 bp | At TSS Multiome | 1066 | |
| chr3:142,586,895–142,587,101 | 8.2 kb | Proximal (<10kb) | 253 | |
| chr3:142,595,928–142,596,960 | 17.6 kb | Distal (>10kb) Multiome | 962 | |
| chr3:142,723,641–142,725,348 | 145.6 kb | Distal (>10kb) Multiome | 876 | |
| chr3:142,863,026–142,863,734 | 284.6 kb | Distal (>10kb) Multiome | 186 | |
| chr3:142,866,818–142,867,310 | 288.3 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the ATR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.