Enables protease binding activity. Involved in negative regulation of exosomal secretion; regulation of endocytic recycling; and regulation of retrograde transport, endosome to Golgi. Located in several cellular components, including endosome; perinuclear region of cytoplasm; and trans-Golgi network membrane. Implicated in neurodevelopmental disorder with poor growth and behavioral abnormalities. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATP9A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP9A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP9A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:51,542,047–51,542,945 | 225.6 kb | Distal (>10kb) Multiome | 490 | |
| chr20:51,562,201–51,563,176 | 205.7 kb | Distal (>10kb) Multiome | 525 | |
| chr20:51,766,950–51,768,471 | 1.0 kb | Proximal (<10kb) Multiome | 740 | |
| chr20:51,797,358–51,798,525 | 29.6 kb | Distal (>10kb) Multiome | 273 | |
| chr20:51,799,751–51,800,876 | 32.1 kb | Distal (>10kb) Multiome | 661 | |
| chr20:51,801,027–51,803,202 | 34.3 kb | Distal (>10kb) Multiome | 615 | |
| chr20:52,049,182–52,049,698 | 281.2 kb | Distal (>10kb) Multiome | 141 |
Genomic view of the ATP9A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.