The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP8B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP8B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP8B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,182,339–154,183,774 | 142.2 kb | Distal (>10kb) Multiome | 934 | |
| chr1:154,220,079–154,221,864 | 104.8 kb | Distal (>10kb) Multiome | 1071 | |
| chr1:154,272,082–154,272,847 | 53.1 kb | Distal (>10kb) Multiome | 834 | |
| chr1:154,324,640–154,326,731 | 701 bp | At TSS Multiome | 685 | |
| chr1:154,328,267–154,328,890 | 3.0 kb | Proximal (<10kb) Multiome | 261 | |
| chr1:154,335,109–154,335,331 | 9.6 kb | Proximal (<10kb) | 374 | |
| chr1:154,352,626–154,353,487 | 27.6 kb | Distal (>10kb) Multiome | 466 | |
| chr1:154,404,987–154,406,067 | 79.9 kb | Distal (>10kb) Multiome | 731 | |
| chr1:154,489,011–154,489,730 | 163.9 kb | Distal (>10kb) Multiome | 82 | |
| chr1:154,493,110–154,493,579 | 167.8 kb | Distal (>10kb) Multiome | 134 | |
| chr1:154,501,716–154,502,717 | 177.1 kb | Distal (>10kb) Multiome | 212 | |
| chr1:154,558,123–154,559,826 | 233.3 kb | Distal (>10kb) Multiome | 1173 | |
| chr1:154,567,476–154,568,396 | 242.4 kb | Distal (>10kb) Multiome | 774 | |
| chr1:154,607,914–154,609,125 | 283.1 kb | Distal (>10kb) Multiome | 720 |
Genomic view of the ATP8B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.