This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP6V1G1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V1G1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V1G1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:114,370,337–114,371,120 | 217.1 kb | Distal (>10kb) Multiome | 151 | |
| chr9:114,387,530–114,388,416 | 199.7 kb | Distal (>10kb) Multiome | 315 | |
| chr9:114,397,621–114,398,973 | 189.4 kb | Distal (>10kb) Multiome | 744 | |
| chr9:114,405,604–114,406,064 | 182.0 kb | Distal (>10kb) Multiome | 266 | |
| chr9:114,409,093–114,409,699 | 178.4 kb | Distal (>10kb) Multiome | 85 | |
| chr9:114,504,150–114,506,064 | 82.2 kb | Distal (>10kb) Multiome | 672 | |
| chr9:114,583,376–114,584,037 | 4.1 kb | Proximal (<10kb) Multiome | 117 | |
| chr9:114,587,169–114,588,239 | 91 bp | At TSS Multiome | 922 | |
| chr9:114,610,961–114,612,019 | 23.8 kb | Distal (>10kb) Multiome | 923 | |
| chr9:114,799,438–114,800,403 | 212.2 kb | Distal (>10kb) Multiome | 162 |
Genomic view of the ATP6V1G1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.