Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in regulation of macroautophagy. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in cytosol. Predicted to be part of proton-transporting two-sector ATPase complex, catalytic domain. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATP6V1E2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V1E2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V1E2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:46,296,415–46,298,276 | 245.3 kb | Distal (>10kb) Multiome | 911 | |
| chr2:46,499,830–46,500,537 | 42.3 kb | Distal (>10kb) Multiome | 657 | |
| chr2:46,541,624–46,542,151 | 614 bp | At TSS Multiome | 610 | |
| chr2:46,542,212–46,544,274 | 56 bp | At TSS Multiome | 785 | |
| chr2:46,551,009–46,551,446 | 8.4 kb | Proximal (<10kb) | 51 | |
| chr2:46,616,071–46,617,512 | 74.5 kb | Distal (>10kb) Multiome | 955 | |
| chr2:46,698,279–46,700,093 | 156.4 kb | Distal (>10kb) Multiome | 974 | |
| chr2:46,704,551–46,705,027 | 162.2 kb | Distal (>10kb) Multiome | 109 |
Genomic view of the ATP6V1E2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.