This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP6V1C1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V1C1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V1C1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:102,806,122–102,807,887 | 213.5 kb | Distal (>10kb) Multiome | 1159 | |
| chr8:102,810,067–102,811,695 | 210.3 kb | Distal (>10kb) Multiome | 1025 | |
| chr8:102,814,226–102,814,970 | 206.3 kb | Distal (>10kb) Multiome | 366 | |
| chr8:102,862,625–102,865,007 | 156.7 kb | Distal (>10kb) Multiome | 1106 | |
| chr8:102,906,209–102,906,703 | 114.7 kb | Distal (>10kb) Multiome | 254 | |
| chr8:102,961,399–102,961,996 | 59.5 kb | Distal (>10kb) Multiome | 268 | |
| chr8:103,020,472–103,021,647 | 51 bp | At TSS Multiome | 842 | |
| chr8:103,140,428–103,141,578 | 119.8 kb | Distal (>10kb) Multiome | 259 | |
| chr8:103,298,291–103,299,527 | 277.9 kb | Distal (>10kb) Multiome | 649 |
Genomic view of the ATP6V1C1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.