Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in vacuolar acidification and vacuolar transport. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATP6V0D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V0D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V0D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:85,987,150–85,987,543 | at TSS | At TSS | 97 | |
| chr8:85,988,190–85,989,087 | 868 bp | At TSS | 53 | |
| chr8:85,989,842–85,990,795 | 2.5 kb | Proximal (<10kb) | 41 | |
| chr8:86,089,596–86,090,017 | 8.9 kb | Proximal (<10kb) | 43 | |
| chr8:86,098,617–86,099,051 | at TSS | At TSS | 68 | |
| chr8:86,103,314–86,103,645 | 4.4 kb | Proximal (<10kb) | 31 |
Genomic view of the ATP6V0D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.