ATP6V0D1

ATPase H+ transporting V0 subunit d1 | ATP6DV, P39, VATX, VPATPD, Vma6, ATP6D

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]

Developmental clusters: GC7

Biological processes 47 terms

apical plasma membrane (GO:0016324)axon terminus (GO:0043679)cellular response to amino acid stimulus (GO:0071230)cellular response to increased oxygen levels (GO:0036295)centrosome (GO:0005813)cilium assembly (GO:0060271)clathrin-coated vesicle membrane (GO:0030665)early endosome (GO:0005769)early endosome (GO:0005769)endosome membrane (GO:0010008)extracellular exosome (GO:0070062)guanyl nucleotide exchange factor activator activity (GO:0160124)homeostatic process (GO:0042592)intracellular iron ion homeostasis (GO:0006879)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal proton-transporting V-type ATPase complex (GO:0046611)membrane (GO:0016020)membrane (GO:0016020)phagocytic vesicle membrane (GO:0030670)phagocytic vesicle membrane (GO:0030670)plasma membrane proton-transporting V-type ATPase complex (GO:0033181)positive regulation of TORC1 signaling (GO:1904263)protein binding (GO:0005515)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)proton transmembrane transport (GO:1902600)proton transmembrane transport (GO:1902600)proton transmembrane transporter activity (GO:0015078)proton-transporting ATPase activity, rotational mechanism (GO:0046961)proton-transporting ATPase activity, rotational mechanism (GO:0046961)proton-transporting ATPase activity, rotational mechanism (GO:0046961)proton-transporting V-type ATPase complex (GO:0033176)proton-transporting V-type ATPase, V0 domain (GO:0033179)regulation of macroautophagy (GO:0016241)synaptic vesicle (GO:0008021)synaptic vesicle lumen acidification (GO:0097401)synaptic vesicle membrane (GO:0030672)vacuolar acidification (GO:0007035)vacuolar proton-transporting V-type ATPase complex (GO:0016471)vacuolar proton-transporting V-type ATPase complex (GO:0016471)vacuolar proton-transporting V-type ATPase complex (GO:0016471)vacuolar proton-transporting V-type ATPase complex (GO:0016471)vacuolar proton-transporting V-type ATPase, V0 domain (GO:0000220)vacuolar transport (GO:0007034)

Expression (TPM)

TFs regulating ATP6V0D1 0 TFs

Transcription factors with Perturb-seq knockdown data for ATP6V0D1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V0D1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ATP6V0D1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V0D1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:67,183,333–67,184,856	297.3 kb	Distal (>10kb) Multiome	886
chr16:67,185,256–67,185,693	295.6 kb	Distal (>10kb) Multiome	740
chr16:67,191,949–67,192,449	289.0 kb	Distal (>10kb) Multiome	781
chr16:67,198,940–67,200,211	281.4 kb	Distal (>10kb) Multiome	325
chr16:67,226,487–67,227,575	254.1 kb	Distal (>10kb) Multiome	909
chr16:67,236,439–67,237,267	244.4 kb	Distal (>10kb) Multiome	195
chr16:67,245,855–67,247,890	233.6 kb	Distal (>10kb) Multiome	1077
chr16:67,248,206–67,249,338	232.1 kb	Distal (>10kb) Multiome	467
chr16:67,262,177–67,262,869	218.7 kb	Distal (>10kb) Multiome	24
chr16:67,278,724–67,279,792	201.8 kb	Distal (>10kb) Multiome	869
chr16:67,326,413–67,327,343	154.3 kb	Distal (>10kb) Multiome	585
chr16:67,393,199–67,393,789	87.6 kb	Distal (>10kb) Multiome	377
chr16:67,396,006–67,396,718	84.7 kb	Distal (>10kb) Multiome	375
chr16:67,399,230–67,399,872	81.6 kb	Distal (>10kb) Multiome	211
chr16:67,415,996–67,416,812	64.7 kb	Distal (>10kb) Multiome	687
chr16:67,428,012–67,428,783	52.8 kb	Distal (>10kb) Multiome	382
chr16:67,430,407–67,432,610	50.0 kb	Distal (>10kb) Multiome	790
chr16:67,480,508–67,481,841	81 bp	At TSS Multiome	1002
chr16:67,489,081–67,489,305	7.9 kb	Proximal (<10kb)	218
chr16:67,521,086–67,521,812	40.3 kb	Distal (>10kb) Multiome HiCAR	775
chr16:67,528,470–67,529,464	47.7 kb	Distal (>10kb) Multiome HiCAR	641
chr16:67,537,215–67,538,620	56.9 kb	Distal (>10kb) Multiome	560
chr16:67,561,597–67,563,672	81.2 kb	Distal (>10kb) Multiome	1044
chr16:67,644,719–67,645,304	163.8 kb	Distal (>10kb) Multiome	638
chr16:67,649,353–67,649,999	168.5 kb	Distal (>10kb) Multiome	112
chr16:67,652,610–67,653,810	171.8 kb	Distal (>10kb) Multiome	498
chr16:67,659,631–67,661,707	179.7 kb	Distal (>10kb) Multiome HiCAR	962
chr16:67,666,180–67,667,235	185.5 kb	Distal (>10kb) Multiome HiCAR	713
chr16:67,667,674–67,668,349	186.9 kb	Distal (>10kb) Multiome HiCAR	628
chr16:67,718,772–67,720,138	238.2 kb	Distal (>10kb) Multiome	866

Genome Browser

Genomic view of the ATP6V0D1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.