This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for ATP6V0B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V0B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V0B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:43,707,108–43,708,162 | 267.4 kb | Distal (>10kb) Multiome | 937 | |
| chr1:43,933,385–43,935,511 | 40.0 kb | Distal (>10kb) Multiome | 565 | |
| chr1:43,935,659–43,937,001 | 38.2 kb | Distal (>10kb) Multiome | 359 | |
| chr1:43,946,199–43,947,337 | 28.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:43,969,717–43,970,284 | 5.0 kb | Proximal (<10kb) Multiome | 515 | |
| chr1:43,974,246–43,975,571 | 87 bp | At TSS Multiome | 875 | |
| chr1:43,978,661–43,979,381 | 4.2 kb | Proximal (<10kb) Multiome | 419 | |
| chr1:43,991,242–43,992,448 | 16.9 kb | Distal (>10kb) Multiome | 780 | |
| chr1:44,000,140–44,000,654 | 25.5 kb | Distal (>10kb) Multiome | 43 | |
| chr1:44,029,597–44,032,070 | 56.7 kb | Distal (>10kb) Multiome | 896 | |
| chr1:44,036,004–44,036,357 | 61.2 kb | Distal (>10kb) Multiome | 452 | |
| chr1:44,134,442–44,134,897 | 159.7 kb | Distal (>10kb) Multiome | 32 | |
| chr1:44,213,251–44,213,777 | 238.5 kb | Distal (>10kb) Multiome | 1062 | |
| chr1:44,238,024–44,238,695 | 263.4 kb | Distal (>10kb) Multiome | 396 | |
| chr1:44,240,892–44,241,669 | 266.3 kb | Distal (>10kb) Multiome | 103 |
Genomic view of the ATP6V0B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.