The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for ATP1A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP1A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP1A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:41,706,740–41,707,217 | 287.1 kb | Distal (>10kb) Multiome | 420 | |
| chr19:41,859,455–41,860,753 | 134.2 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:41,883,883–41,884,651 | 109.8 kb | Distal (>10kb) Multiome | 917 | |
| chr19:41,927,700–41,928,620 | 65.9 kb | Distal (>10kb) Multiome | 277 | |
| chr19:41,957,648–41,959,799 | 34.6 kb | Distal (>10kb) Multiome | 839 | |
| chr19:41,993,779–41,994,412 | 125 bp | At TSS Multiome | 360 | |
| chr19:41,997,205–41,997,569 | 3.1 kb | Proximal (<10kb) | 257 | |
| chr19:41,998,577–41,999,349 | 4.8 kb | Proximal (<10kb) Multiome | 292 | |
| chr19:42,075,557–42,076,657 | 82.0 kb | Distal (>10kb) Multiome | 846 | |
| chr19:42,095,735–42,096,278 | 101.9 kb | Distal (>10kb) Multiome | 107 | |
| chr19:42,132,949–42,133,545 | 139.2 kb | Distal (>10kb) Multiome | 447 | |
| chr19:42,176,787–42,177,398 | 183.1 kb | Distal (>10kb) Multiome | 381 | |
| chr19:42,216,521–42,218,719 | 223.6 kb | Distal (>10kb) Multiome | 841 | |
| chr19:42,219,693–42,220,678 | 226.2 kb | Distal (>10kb) Multiome | 735 | |
| chr19:42,241,985–42,243,820 | 248.9 kb | Distal (>10kb) Multiome | 891 | |
| chr19:42,244,086–42,245,258 | 250.8 kb | Distal (>10kb) Multiome | 768 | |
| chr19:42,253,030–42,256,178 | 261.2 kb | Distal (>10kb) Multiome | 900 | |
| chr19:42,267,812–42,269,463 | 274.8 kb | Distal (>10kb) Multiome | 887 | |
| chr19:42,279,620–42,280,909 | 286.0 kb | Distal (>10kb) Multiome | 818 | |
| chr19:42,283,173–42,285,280 | 289.9 kb | Distal (>10kb) Multiome | 739 |
Genomic view of the ATP1A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.