The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for ATP1A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP1A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP1A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,853,905–159,855,297 | 261.1 kb | Distal (>10kb) Multiome | 474 | |
| chr1:159,899,910–159,900,706 | 215.5 kb | Distal (>10kb) Multiome | 349 | |
| chr1:159,922,909–159,926,224 | 190.2 kb | Distal (>10kb) Multiome | 922 | |
| chr1:159,929,315–159,930,329 | 186.0 kb | Distal (>10kb) Multiome | 235 | |
| chr1:159,936,265–159,937,075 | 179.2 kb | Distal (>10kb) Multiome | 355 | |
| chr1:159,945,025–159,946,368 | 170.0 kb | Distal (>10kb) Multiome | 624 | |
| chr1:160,031,268–160,032,381 | 83.8 kb | Distal (>10kb) Multiome | 780 | |
| chr1:160,046,290–160,047,082 | 69.0 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 45.3 kb | Distal (>10kb) Multiome | 419 | |
| chr1:160,083,809–160,084,575 | 31.5 kb | Distal (>10kb) Multiome | 327 | |
| chr1:160,095,707–160,096,231 | 19.8 kb | Distal (>10kb) Multiome | 79 | |
| chr1:160,097,214–160,099,572 | 16.9 kb | Distal (>10kb) Multiome | 659 | |
| chr1:160,100,845–160,101,543 | 14.6 kb | Distal (>10kb) Multiome | 530 | |
| chr1:160,115,573–160,115,783 | at TSS | At TSS | 44 | |
| chr1:160,169,049–160,170,141 | 54.0 kb | Distal (>10kb) Multiome | 330 | |
| chr1:160,192,913–160,193,769 | 77.6 kb | Distal (>10kb) Multiome | 551 | |
| chr1:160,204,860–160,206,035 | 89.6 kb | Distal (>10kb) Multiome | 637 | |
| chr1:160,261,515–160,263,143 | 146.7 kb | Distal (>10kb) Multiome | 992 | |
| chr1:160,284,609–160,285,332 | 169.4 kb | Distal (>10kb) Multiome | 638 | |
| chr1:160,342,945–160,343,700 | 227.6 kb | Distal (>10kb) Multiome | 868 | |
| chr1:160,399,764–160,401,441 | 284.7 kb | Distal (>10kb) Multiome | 590 |
Genomic view of the ATP1A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.