Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATP1A1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP1A1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP1A1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:116,138,890–116,139,376 | 279.4 kb | Distal (>10kb) Multiome HiCAR | 625 | |
| chr1:116,151,870–116,152,550 | 266.4 kb | Distal (>10kb) Multiome HiCAR | 538 | |
| chr1:116,167,654–116,168,661 | 250.1 kb | Distal (>10kb) Multiome HiCAR | 379 | |
| chr1:116,372,503–116,374,831 | 45.4 kb | Distal (>10kb) Multiome | 903 | |
| chr1:116,415,510–116,416,727 | 2.6 kb | Proximal (<10kb) Multiome | 525 | |
| chr1:116,418,287–116,418,947 | 11 bp | At TSS Multiome | 835 | |
| chr1:116,420,956–116,421,526 | 2.5 kb | Proximal (<10kb) Multiome | 81 | |
| chr1:116,485,040–116,485,738 | 66.8 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr1:116,569,966–116,571,655 | 152.4 kb | Distal (>10kb) Multiome | 829 | |
| chr1:116,666,816–116,668,150 | 249.1 kb | Distal (>10kb) Multiome | 530 |
Genomic view of the ATP1A1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.