The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for ATP12A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP12A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP12A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:24,512,235–24,513,091 | 167.7 kb | Distal (>10kb) Multiome | 867 | |
| chr13:24,591,684–24,592,420 | 88.4 kb | Distal (>10kb) Multiome | 20 | |
| chr13:24,671,001–24,671,324 | 9.1 kb | Proximal (<10kb) | 160 | |
| chr13:24,671,451–24,671,686 | 8.7 kb | Proximal (<10kb) | 183 | |
| chr13:24,680,076–24,681,056 | 70 bp | At TSS Multiome | 266 | |
| chr13:24,683,924–24,684,193 | 3.5 kb | Proximal (<10kb) | 231 | |
| chr13:24,714,126–24,714,653 | 34.0 kb | Distal (>10kb) Multiome HiCAR | 40 | |
| chr13:24,715,820–24,716,895 | 35.9 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr13:24,746,528–24,747,148 | 66.5 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr13:24,922,363–24,923,209 | 242.5 kb | Distal (>10kb) Multiome | 771 |
Genomic view of the ATP12A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.