P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Transcription factors with Perturb-seq knockdown data for ATP11B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP11B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP11B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:182,682,115–182,683,252 | 111.0 kb | Distal (>10kb) Multiome | 512 | |
| chr3:182,715,815–182,716,851 | 77.3 kb | Distal (>10kb) Multiome | 248 | |
| chr3:182,792,849–182,794,466 | 18 bp | At TSS Multiome | 803 | |
| chr3:182,979,737–182,981,250 | 187.0 kb | Distal (>10kb) Multiome | 562 | |
| chr3:183,009,852–183,010,416 | 216.5 kb | Distal (>10kb) Multiome | 225 |
Genomic view of the ATP11B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.