This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for ATL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,489,897–63,491,487 | 180.7 kb | Distal (>10kb) Multiome | 254 | |
| chr11:63,491,633–63,492,303 | 179.8 kb | Distal (>10kb) Multiome | 264 | |
| chr11:63,503,095–63,503,560 | 168.4 kb | Distal (>10kb) Multiome | 72 | |
| chr11:63,613,506–63,614,656 | 57.3 kb | Distal (>10kb) Multiome | 502 | |
| chr11:63,670,776–63,672,118 | 63 bp | At TSS Multiome | 715 | |
| chr11:63,680,920–63,682,270 | 9.7 kb | Proximal (<10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 92.4 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 95.8 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 141.7 kb | Distal (>10kb) Multiome | 704 | |
| chr11:63,838,214–63,839,799 | 167.2 kb | Distal (>10kb) Multiome | 687 | |
| chr11:63,888,171–63,888,861 | 216.8 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 238.2 kb | Distal (>10kb) Multiome | 113 | |
| chr11:63,916,069–63,921,372 | 247.7 kb | Distal (>10kb) Multiome | 929 | |
| chr11:63,938,087–63,939,846 | 267.1 kb | Distal (>10kb) Multiome | 852 |
Genomic view of the ATL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.