Enables identical protein binding activity. Involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Located in endoplasmic reticulum tubular network membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ATL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:38,095,584–38,097,105 | 281.1 kb | Distal (>10kb) Multiome | 485 | |
| chr2:38,277,670–38,278,397 | 99.2 kb | Distal (>10kb) Multiome | 96 | |
| chr2:38,376,242–38,378,169 | 199 bp | At TSS Multiome | 1082 | |
| chr2:38,380,205–38,380,558 | 2.9 kb | Proximal (<10kb) | 111 | |
| chr2:38,432,787–38,433,235 | 55.7 kb | Distal (>10kb) Multiome HiCAR | 614 | |
| chr2:38,440,476–38,441,570 | 63.7 kb | Distal (>10kb) Multiome HiCAR | 331 | |
| chr2:38,442,985–38,445,041 | 67.4 kb | Distal (>10kb) Multiome HiCAR | 354 | |
| chr2:38,535,703–38,536,446 | 159.0 kb | Distal (>10kb) Multiome | 711 | |
| chr2:38,542,771–38,543,473 | 165.9 kb | Distal (>10kb) Multiome | 516 | |
| chr2:38,601,968–38,603,924 | 225.8 kb | Distal (>10kb) Multiome | 1077 | |
| chr2:38,665,660–38,666,774 | 288.8 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the ATL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.