The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for ATG16L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG16L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG16L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:232,875,994–232,877,248 | 375.1 kb | Distal (>10kb) Multiome HiCAR | 488 | |
| chr2:233,051,257–233,052,137 | 199.9 kb | Distal (>10kb) Multiome | 218 | |
| chr2:233,129,373–233,130,063 | 122.0 kb | Distal (>10kb) Multiome | 111 | |
| chr2:233,139,260–233,139,740 | 112.3 kb | Distal (>10kb) Multiome | 98 | |
| chr2:233,251,235–233,252,102 | 57 bp | At TSS Multiome | 955 | |
| chr2:233,353,271–233,354,945 | 102.7 kb | Distal (>10kb) Multiome | 679 | |
| chr2:233,408,408–233,410,885 | 157.4 kb | Distal (>10kb) Multiome | 338 |
Genomic view of the ATG16L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.