This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for ATE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:120,948,941–120,949,508 | 979.4 kb | Distal (>10kb) Multiome HiCAR | 424 | |
| chr10:120,981,508–120,982,509 | 946.5 kb | Distal (>10kb) Multiome HiCAR | 187 | |
| chr10:121,002,715–121,003,391 | 925.4 kb | Distal (>10kb) Multiome HiCAR | 93 | |
| chr10:121,891,008–121,891,561 | 37.1 kb | Distal (>10kb) Multiome | 140 | |
| chr10:121,921,559–121,921,861 | 6.2 kb | Proximal (<10kb) | 35 | |
| chr10:121,927,427–121,928,651 | 389 bp | At TSS Multiome | 904 | |
| chr10:121,974,336–121,975,594 | 46.7 kb | Distal (>10kb) Multiome | 875 | |
| chr10:122,112,641–122,114,050 | 184.5 kb | Distal (>10kb) Multiome | 855 | |
| chr10:122,162,689–122,164,583 | 235.0 kb | Distal (>10kb) Multiome | 396 |
Genomic view of the ATE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.