This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for ATAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,325,606–30,327,611 | 299.9 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:30,344,843–30,345,715 | 281.6 kb | Distal (>10kb) Multiome | 892 | |
| chr6:30,357,696–30,358,238 | 269.0 kb | Distal (>10kb) Multiome | 207 | |
| chr6:30,466,230–30,466,713 | 160.3 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 136.6 kb | Distal (>10kb) Multiome | 750 | |
| chr6:30,516,006–30,516,707 | 110.5 kb | Distal (>10kb) Multiome | 739 | |
| chr6:30,555,407–30,557,765 | 70.2 kb | Distal (>10kb) Multiome | 1161 | |
| chr6:30,570,822–30,571,949 | 55.5 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:30,614,393–30,615,939 | 11.7 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 9.3 kb | Proximal (<10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 15 bp | At TSS Multiome | 802 | |
| chr6:30,646,505–30,648,035 | 20.4 kb | Distal (>10kb) Multiome | 961 | |
| chr6:30,672,571–30,673,266 | 46.1 kb | Distal (>10kb) Multiome | 812 | |
| chr6:30,679,032–30,679,479 | 52.3 kb | Distal (>10kb) Multiome | 603 | |
| chr6:30,686,268–30,688,032 | 60.4 kb | Distal (>10kb) Multiome | 801 | |
| chr6:30,690,445–30,691,240 | 64.1 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,716,986–30,717,874 | 90.6 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:30,719,428–30,720,577 | 93.3 kb | Distal (>10kb) Multiome | 724 | |
| chr6:30,721,307–30,722,103 | 94.6 kb | Distal (>10kb) Multiome | 872 | |
| chr6:30,725,731–30,726,564 | 99.3 kb | Distal (>10kb) Multiome | 478 | |
| chr6:30,740,996–30,745,094 | 115.9 kb | Distal (>10kb) Multiome | 1233 | |
| chr6:30,763,647–30,765,193 | 137.6 kb | Distal (>10kb) Multiome | 850 | |
| chr6:30,880,638–30,881,295 | 254.1 kb | Distal (>10kb) Multiome | 124 | |
| chr6:30,882,560–30,883,422 | 256.0 kb | Distal (>10kb) Multiome | 308 | |
| chr6:30,883,625–30,885,122 | 257.5 kb | Distal (>10kb) Multiome | 538 | |
| chr6:30,907,770–30,908,494 | 281.2 kb | Distal (>10kb) Multiome | 1005 | |
| chr6:30,913,674–30,914,800 | 287.3 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the ATAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.