Predicted to enable ATP hydrolysis activity. Involved in extraction of mislocalized protein from mitochondrial outer membrane. Located in mitochondrial outer membrane and peroxisomal membrane. Implicated in hyperekplexia 4. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:87,658,548–87,660,459 | 158.3 kb | Distal (>10kb) Multiome | 507 | |
| chr10:87,734,828–87,735,531 | 83.0 kb | Distal (>10kb) Multiome | 289 | |
| chr10:87,817,687–87,819,379 | 40 bp | At TSS Multiome | 867 | |
| chr10:87,861,521–87,864,430 | 45.3 kb | Distal (>10kb) Multiome | 1208 | |
| chr10:87,915,332–87,915,810 | 97.4 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the ATAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.