This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for ASTN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASTN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASTN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:115,494,943–115,495,875 | 1919.7 kb | Distal (>10kb) Multiome HiCAR | 383 | |
| chr9:116,686,450–116,688,091 | 727.7 kb | Distal (>10kb) Multiome | 730 | |
| chr9:116,715,244–116,716,341 | 699.1 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr9:116,764,895–116,765,572 | 649.9 kb | Distal (>10kb) Multiome | 32 | |
| chr9:116,791,054–116,791,798 | 623.6 kb | Distal (>10kb) Multiome | 121 | |
| chr9:116,826,465–116,827,102 | 588.3 kb | Distal (>10kb) Multiome | 14 | |
| chr9:116,952,484–116,953,593 | 462.0 kb | Distal (>10kb) Multiome | 122 | |
| chr9:117,155,462–117,155,990 | 259.5 kb | Distal (>10kb) Multiome HiCAR | 42 | |
| chr9:117,406,481–117,406,659 | 8.4 kb | Proximal (<10kb) | 59 | |
| chr9:117,411,481–117,412,657 | 2.4 kb | Proximal (<10kb) | 157 | |
| chr9:117,412,773–117,416,127 | 110 bp | At TSS Multiome | 446 | |
| chr9:117,487,317–117,488,269 | 72.7 kb | Distal (>10kb) Multiome | 611 | |
| chr9:117,687,017–117,687,921 | 272.6 kb | Distal (>10kb) Multiome | 124 |
Genomic view of the ASTN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.