The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ASB7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASB7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASB7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:100,340,630–100,342,607 | 260.5 kb | Distal (>10kb) Multiome | 629 | |
| chr15:100,349,411–100,350,616 | 252.5 kb | Distal (>10kb) Multiome | 588 | |
| chr15:100,601,291–100,601,607 | 999 bp | At TSS | 106 | |
| chr15:100,601,704–100,603,366 | 168 bp | At TSS Multiome | 808 | |
| chr15:100,703,026–100,703,737 | 100.8 kb | Distal (>10kb) Multiome | 232 | |
| chr15:100,759,705–100,760,315 | 157.4 kb | Distal (>10kb) Multiome | 302 | |
| chr15:100,878,673–100,880,993 | 277.0 kb | Distal (>10kb) Multiome | 455 | |
| chr15:101,651,697–101,653,159 | 1049.8 kb | Distal (>10kb) Multiome HiCAR | 1015 |
Genomic view of the ASB7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.