This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for ASAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:23,216,791–23,217,828 | 267.2 kb | Distal (>10kb) Multiome | 415 | |
| chr1:23,343,731–23,344,999 | 139.7 kb | Distal (>10kb) Multiome | 939 | |
| chr1:23,367,863–23,369,864 | 115.8 kb | Distal (>10kb) Multiome | 1018 | |
| chr1:23,370,752–23,371,596 | 113.1 kb | Distal (>10kb) Multiome | 344 | |
| chr1:23,403,774–23,404,231 | 80.2 kb | Distal (>10kb) Multiome | 536 | |
| chr1:23,436,460–23,437,402 | 47.4 kb | Distal (>10kb) Multiome | 248 | |
| chr1:23,483,306–23,485,071 | 222 bp | At TSS Multiome | 659 | |
| chr1:23,530,568–23,531,711 | 47.1 kb | Distal (>10kb) Multiome HiCAR | 775 | |
| chr1:23,539,704–23,540,280 | 55.8 kb | Distal (>10kb) Multiome HiCAR | 668 | |
| chr1:23,554,367–23,556,627 | 70.7 kb | Distal (>10kb) Multiome | 961 | |
| chr1:23,558,135–23,559,925 | 75.4 kb | Distal (>10kb) Multiome | 932 | |
| chr1:23,598,114–23,599,073 | 114.4 kb | Distal (>10kb) Multiome | 329 | |
| chr1:23,691,587–23,692,258 | 207.6 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr1:23,742,958–23,744,137 | 259.1 kb | Distal (>10kb) Multiome | 802 | |
| chr1:23,777,908–23,778,814 | 294.1 kb | Distal (>10kb) Multiome | 849 |
Genomic view of the ASAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.