Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for ARRB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARRB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARRB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,498,488–4,499,859 | 211.8 kb | Distal (>10kb) Multiome | 361 | |
| chr17:4,555,276–4,555,773 | 155.2 kb | Distal (>10kb) Multiome | 806 | |
| chr17:4,583,931–4,585,086 | 126.3 kb | Distal (>10kb) Multiome | 323 | |
| chr17:4,703,669–4,704,637 | 6.5 kb | Proximal (<10kb) Multiome | 854 | |
| chr17:4,708,553–4,709,232 | 1.9 kb | Proximal (<10kb) Multiome | 71 | |
| chr17:4,709,724–4,711,094 | 195 bp | At TSS Multiome | 771 | |
| chr17:4,730,794–4,732,115 | 21.0 kb | Distal (>10kb) Multiome | 936 | |
| chr17:4,745,124–4,745,511 | 34.8 kb | Distal (>10kb) Multiome | 67 | |
| chr17:4,789,618–4,790,520 | 79.6 kb | Distal (>10kb) Multiome | 816 | |
| chr17:4,795,974–4,796,433 | 85.5 kb | Distal (>10kb) Multiome | 751 | |
| chr17:4,806,693–4,807,619 | 96.5 kb | Distal (>10kb) Multiome | 494 | |
| chr17:4,832,863–4,833,956 | 122.7 kb | Distal (>10kb) Multiome | 730 | |
| chr17:4,898,962–4,900,112 | 188.8 kb | Distal (>10kb) Multiome | 257 | |
| chr17:4,900,249–4,901,057 | 190.2 kb | Distal (>10kb) Multiome | 145 | |
| chr17:4,909,117–4,909,538 | 198.6 kb | Distal (>10kb) Multiome | 553 | |
| chr17:4,939,475–4,941,034 | 229.5 kb | Distal (>10kb) Multiome | 821 | |
| chr17:4,947,426–4,950,636 | 239.5 kb | Distal (>10kb) Multiome | 1080 | |
| chr17:4,966,739–4,968,875 | 256.9 kb | Distal (>10kb) Multiome | 982 | |
| chr17:4,986,950–4,987,983 | 276.9 kb | Distal (>10kb) Multiome | 881 | |
| chr17:4,996,838–4,998,964 | 287.1 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the ARRB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.