This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for ARPC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:110,223,831–110,224,526 | 226.3 kb | Distal (>10kb) Multiome | 199 | |
| chr12:110,280,425–110,282,158 | 169.1 kb | Distal (>10kb) Multiome | 888 | |
| chr12:110,403,190–110,403,822 | 46.6 kb | Distal (>10kb) Multiome | 779 | |
| chr12:110,431,453–110,431,925 | 18.7 kb | Distal (>10kb) Multiome | 461 | |
| chr12:110,449,732–110,450,544 | 18 bp | At TSS Multiome | 883 | |
| chr12:110,468,018–110,469,597 | 19.0 kb | Distal (>10kb) Multiome HiCAR | 1093 | |
| chr12:110,501,642–110,502,585 | 51.9 kb | Distal (>10kb) Multiome | 1115 | |
| chr12:110,582,284–110,583,969 | 133.0 kb | Distal (>10kb) Multiome | 740 | |
| chr12:110,613,705–110,614,482 | 163.7 kb | Distal (>10kb) Multiome | 791 | |
| chr12:110,688,496–110,690,180 | 239.0 kb | Distal (>10kb) Multiome | 414 | |
| chr12:110,742,238–110,743,370 | 292.7 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the ARPC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.